Facinelli made his feature film debut in Rebecca Miller's Angela in 1995 and came to the attention of critics in the TV-movie The Price of Love later that year. In 1996, Facinelli played opposite future wife Jennie Garth in An Unfinished Affair. Other TV roles followed, including a part in After Jimmy (1996) and a college dropout in Calm at Sunset. Facinelli co-starred with Amanda Peet and Michael Vartan in the 1997 AIDS-themed drama Touch Me (1997) and co-starred as a high school student in two 1998 features with Ethan Embry and Breckin Meyer, Dancer, Texas Pop. 81, and Can't Hardly Wait, which starred Jennifer Love Hewitt.

Facinelli appeared in the sci-fi film Supernova starring James Spader in 2000. He made appearances in Riding in Cars with Boys in 2001 and The Scorpion King in 2002, followed by a leading role in the Fox drama Fastlane. Facinelli had a recurring role in the HBO series Six Feet Under in 2004 and a role in the FX original series Damages beginning in 2007. Facinelli starred in Hollow Man 2 with Christian Slater. It was released direct-to-video in May 2006.

After wrapping up Finding Amanda with Matthew Broderick, Facinelli played Carlisle Cullen in the film adaptation of Twilight, based on the book by Stephenie Meyer. Facinelli reprised his role in the sequels of the film, The Twilight Saga: New Moon, and The Twilight Saga: Eclipse. He will also continue to portray the role in The Twilight Saga: Breaking Dawn Part 1 and The Twilight Saga: Breaking Dawn Part 2, which are set to be released November 18, 2011 and November 16, 2012 respectively.

He stars as Dr. Fitch Cooper in the Showtime dark comedy series Nurse Jackie. Additionally, Peter is making his mark behind the scenes. Currently, he stars in the independent film Loosies, a story of a New York pickpocket that he wrote himself and being produced by Verdi Corrente Productions. Peter is also writing and producing and starring in the upcoming film, El Chico Blanco, the story of an outcast raised in the barrio who rises to a position of power within a crime family for Facinelli Films, currently in pre-production. Along with El Chico Blanco, Peter is producing the upcoming film, Street Soldier, the story of Boston mobster Whitey Bulger, the long-time leader of the Irish-American Winter Hill Gang, currently in pre-production for Facinelli Films and Brookstone Pictures.

Full Credits at IMDB.com